testing testing ..read more

Shots: Sol-Gel Technologies has entered into an asset purchase agreement with Shenzhen Beimei Pharmaceutical to commercialize Twyneo for treating acne vulgaris across mainland China, Hong Kong, Macau, Taiwan & Israel As per the agreement, Beimei gains exclusive commercialization rights to Twyneo across those regions. Sol-Gel is entitled to receive an aggregate of $10M which includes upfront and milestones plus up to $5M net-sales-based royalty The company also anticipates future collaborations for the commercialization of both Twyneo and Epsolay across other regions Ref: Sol-Gel Techn ..read more

Shots: Johnson & Johnson has agreed to acquire Proteologix to expand its dermatology portfolio for an aggregate of $850M in cash The acquisition adds Proteologix’s PX128, which will be entering P-I clinical evaluation to treat severe atopic dermatitis (AD) & moderate to severe asthma as well as PX130, currently under preclinical evaluation for moderate to severe AD, along with additional bispecific antibody programs for a range of diseases to J&J’s portfolio      PX128 works by inhibiting IL-13-mediated Th2 skin inflammation and TSLP-mediated tissue inflammation whil ..read more

When we talk about healing, it's often more than just physical recovery; it encompasses emotional and mental restoration as well. Whether recovering from an injury, surgery, or a psychological stressor, the process can sometimes feel slow and frustrating. However, there are several strategies that can help speed up this process, ensuring a more effective and efficient recovery. This article delves into some diverse methods that not only support physical healing but also foster emotional well-being.   1. Adopting a Nutrient-Rich Diet  One of the most fundamental ways to enhance y ..read more

When it comes to our well-being, cultivating close relationships with our friends is essential.  Friendship supports our mental and emotional wellness in several ways. The social connection provided by close friendship can combat the negative side effects of isolation - staving off deeper psychological issues such as extreme loneliness, anxiety, and depression.  The emotional support we receive from our chosen family - aka, our friendship circle - can also help us through times of trauma, crisis, and stress.   And - if Sex and the City’s Carrie, Miranda, Samantha, and Charl ..read more

Shots: The US FDA has granted accelerated approval to Amgen’s Imdelltra (DLL3-targeting bispecific T-cell engager) for treating extensive-stage small cell lung cancer (ES-SCLC) adults whose disease progressed post Pt-based CT. Full approval depends upon confirmatory trials The approval was based on the P-II (DeLLphi-301) study assessing Imdelltra (10mg, Q2W) in SCLC patients (n=99) failing on 2 or more previous lines of treatment & administered with the 10mg Q2W dosing regimen The results depicted an ORR of 40%, mDoR of 9.7mos. and mOS of 14.3mos. Further evaluation continues for complete ..read more

Shots: HUTCHMED has reported the P-III (ESLIM‑01) study data of sovleplenib (oral) vs PBO in primary Immune Thrombocytopenia (ITP) adults (n=188) previously treated with at least one line of standard therapy in China and will highlight data of HMPL-306, HMPL-760 & tazemetostat at EHA 2024 The study depicted a durable response rate of 48.4% vs 0%, median TTR of 1.1wks., improved physical functioning & energy/fatigue plus a tolerable safety profile with grade ≥3 TEAEs in 25.4% (sovleplenib) vs 24.2% (PBO) of patients The company will also present the P-II data from P-II/III (ESLIM-02) tr ..read more

Shots: The P-III (POETYK PSO-1; n=666 & POETYK PSO-2; n=1,020) studies assessed Sotyktu's (6mg, QD) safety & efficacy vs PBO & Otezla (30mg, BID) to treat moderate-to-severe plaque psoriasis The efficacy evaluable patients (n=513), progressed from both trials to the POETYK PSO-LTE study, showed 71.7% PASI 75 (yr.1: 72.0%; yr.3: 73.8%) at yr.4, 47.5% PASI 90 (yr.1: 45.6%; yr.3: 49.0%) & 57.2% sPGA 0/1 (yr.1: 57.7%; yr.3: 55.2%)  The safety evaluable patients (n=1,519) with cumulative exposure to Sotyktu of 4,392.8 PYs showed reduced or same EAIRs/100 PYs from yr.1 to 4 for ..read more

Shots: The US FDA has granted clearance to the company’s Hotwire radiofrequency (RF) guidewire device facilitating zero exchange left-heart access and serving as a rail for catheter-based therapy systems The Hotwire system offers universal sheath compatibility and optimized RF technology to enhance patient outcomes and for efficient procedural workflows   Atraverse also generated funding of $12.5M in total seed investment led by physicians, venture investors and medtech entrepreneurs to support the company’s research, development & commercialization activities  Ref: PR ..read more

Shots:  A rare autoimmune condition, Sjögren’s Syndrome is characterized by dry mouth and eye. The condition affects 0.5 to 1% of the global population of which 90% of patients are women  In this reprise of our Disease of the Month report, we bring an illuminating account of Sjögren’s Syndrome with deep dive analysis of epidemiology, market size, disease management, available therapies, patient advocacy groups, and the key players involved   For a curated report, reach out to us at connect@pharmashots.com  A chronic autoimmune di ..read more