The dynamic landscape of scientific research continues to evolve, driven by innovation in technology, novel methodologies and the growing demand for breakthrough discoveries. Central to many scientific investigations are human biological samples (HBS), which often serve as the foundational materials that critical research is built on. As a trusted platform that handles thousands of requests for HBS annually and has supported access to over 10 million individual human biological samples since 2015, Scientist.com enables the easy, compliant and competitive sourcing of HBS across the biopharma i ..read more

This blog post was written by Transpharmation, a global leader in translational biology. The Blood-Brain, Blood-CSF and Blood-Arachnoid Barriers For drugs acting in the central nervous system (CNS), it is assumed that the unbound drug in the brain interstitial fluid (ISF) is available to interact with the target site in the CNS. Estimating or measuring the unbound brain ISF concentration is not straightforward. Unbound plasma exposure of drugs in most cases is not suitable to describe the correlation between pharmacokinetics and pharmacodynamics, mainly due to the restrictive role of the blood ..read more

Scientist.com ranked #3 in culture on Fortune’s list of the Most Innovative Companies The strength of a company’s culture can greatly impact the overall health and success of an organization. According to Forbes, companies with a strong company culture have up to 72% higher employee engagement than companies with poor culture.1 It becomes evident that establishing a company culture that is not only understood by its employees but also supported by them is crucial for the organization’s success. Developing a robust company culture presents significant challenges, particularly for global organiz ..read more

This blog post was written by TD2, an oncology CRO dedicated to precision medicine that works with innovative biotech and pharma companies to bring rare cancer treatments to patients as quickly as possible. In the sphere of immuno-oncology research, a powerful tool has emerged - the Diet-Induced Obesity (DIO) mouse model. These models provide researchers a practical route to understanding the connections between obesity, immunity, and cancer treatment. The real value of DIO mice lies in their ability to reflect human-like responses, marking a new phase of discovery. Below are the top 5 reasons ..read more

This blog post was written by Silvia Grama and Philippe Saint Cricq Riviere from Fortis Life Sciences. Fortis partners with diagnostics and life sciences companies to design, validate, and manufacture solutions to solve their complex development problems. Multi-functional nanoparticles are gaining attention in nanomedicine due to their unique capabilities. Nanoparticles can deliver specific compounds, target locations and destroy cells once they reach their destination. Functionalities like fluorescence, magnetism, light scattering and drug delivery can be incorporated. In many cases, biomolec ..read more

This installment of Tech Snapshot®, written by Crown Bioscience, emphasizes the importance of using patient-relevant tumor organoids for high throughput drug screening in cancer research. The case study presented showcases the advantages of an assay-ready (AR) organoid platform, demonstrating reduced timelines, repeatability and suitability for extensive panel assessments. The pharmaceutical industry has traditionally relied on 2D cancer cell lines for in vitro anticancer drug screens. Although this system is relevant for many uses, it is recognized that there is a limited correlation between ..read more

This blog post was written by Kimberly Quart and Stephanie Morris from Fortis Life Sciences. Fortis partners with diagnostics and life sciences companies to design, validate, and manufacture solutions to solve their complex development problems. Nanomedicine is a rapidly advancing field that utilizes nanotechnology to revolutionize medical applications. At the nanoscale, materials exhibit unique properties that hold the potential to transform drug delivery, imaging, diagnostics and therapeutics. Among the various nanomaterials being explored, gold and silica nanoparticles have garnered signifi ..read more

Earlier this year, Scientist.com launched its inaugural STEM Research Award, our own twist on the NCAA’s 2019 NIL rule. You may be wondering, “What does an NCAA rule have to do with STEM researchers?” Well, a lot more than you’d think. “There are at least 10 US universities that bring in over $100 million in athletic revenue per year, so the NIL rule makes sense,” stated Dan Kagan, PhD, President and COO at Scientist.com. “We started the STEM NIL Award in recognition of the fact that there are at least 20 US universities that generate over $1 billion in research revenue annually, but undergra ..read more

What is a Cyclic Peptide? Peptides possess distinctive characteristics that render them highly attractive as therapeutic agents. Cyclic peptides are a group of peptide subtype containing one or more cyclic structures produced through end-to-end, cephalic or side-chain-to-side-chain cyclization reactions. Cyclic peptides are mostly composed of 5-30 amino acids, with a molecular weight between 500-3000 Da. Cyclic peptides continue to be one of the most alluring prospects in modern drug discovery endeavors due to their relatively small size, capacity to selectively and strongly interact with thei ..read more

Picture this: a 44 year-old Massachusetts woman runs a black market body part business from her Salem storefront, “Kat’s Creepy Creations”. Sounds like the plot of a horror movie right? Well, unfortunately this was a real headline from a recent article, detailing the story of a nationwide network of individuals who were buying and selling stolen human remains from Harvard Medical School and an Arkansas mortuary. If you’ve been a longtime reader of our blog, you might remember a post published in 2018 depicting a similarly chilling story. It was a problem five years ago, and it still very much ..read more