New publication in Advanced Materials!
Medicinal Polymer Chemistry Lab
by admin
4M ago
Zymogens and Transmembrane Activation of Transcription in Synthetic Cells Andersen, D. G., Pedersen, A. B., Jørgensen, M. H., Montasell, M. C., Søgaard, A. B., Chen, G., Schroeder, A., Andersen, G. R., Zelikin, A. N., Zymogens and Transmembrane Activation of Transcription in Synthetic Cells. Adv. Mater. 2023, 2309385. DOI: https://doi.org/10.1002/adma.202309385 Abstract In this work, we engineer synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular tran ..read more
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?Halloween party?
Medicinal Polymer Chemistry Lab
by admin
5M ago
The scariest time of the year was celebrated in style with a costume party on the night of Halloween ..read more
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Read our newest publication in ACS Macro Letters!
Medicinal Polymer Chemistry Lab
by admin
6M ago
Mechanisms of Degradation for Polydisulfides: Main Chain Scission, Self-Immolation, Or Chain Transfer Depolymerization Kristensen, M. M.; Løvschall, K. B.; Zelikin, A. N., Mechanisms of Degradation for Polydisulfides: Main Chain Scission, Self-Immolation, Or Chain Transfer Depolymerization. ACS Macro Lett. 2023, 955-960. DOI: https://doi.org/10.1021/acsmacrolett.3c00345 Abstract Organic polydisulfides hold immense potential for the design of recyclable materials. Of these, polymers based on lipoic acid are attractive, as they are based on a natural, renewable resource. Herein, we demonstrate t ..read more
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New publication in Advanced science! Treatment of bacterial biofilms with antibody-drug conjugates
Medicinal Polymer Chemistry Lab
by admin
10M ago
“Antibody-Drug Conjugates to Treat Bacterial Biofilms viaTargeting and Extracellular Drug Release” https://doi.org/10.1002/advs.202301340 Abstract The treatment of implant-associated bacterial infections and biofilms is an urgent medical need and a grand challenge because biofilms protect bacteria from the immune system and harbor antibiotic-tolerant persister cells. This need is addressed herein through an engineering of antibody-drug conjugates (ADCs) that contain an anti-neoplastic drug mitomycin C, which is also a potent antimicrobial against biofilms. The ADCs designed herein release the ..read more
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New publication in Nature Communications!
Medicinal Polymer Chemistry Lab
by admin
1y ago
Signal transduction across biological membranes is among the most important evolutionary achievements. Herein, for the design of artificial cells, we engineer fully synthetic receptors with the capacity of transmembrane signaling, using tools of chemistry. Our receptors exhibit similarity with their natural counterparts in having an exofacial ligand for signal capture, being membrane anchored, and featuring a releasable messenger molecule that performs enzyme activation as a downstream signaling event. The main difference from natural receptors is the mechanism of signal transduction, which is ..read more
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PhD student Josefine Hammer Jakobsen presents her project at “Girls’ Day in Science”
Medicinal Polymer Chemistry Lab
by admin
1y ago
On October 5. PhD student in the Zelikin group, Josefine Hammer Jakobsen, presented her science to a group of girls from danish high schools that might be interested in pursuing an education within the natural sciences. Girls in danish high schools were invited to visit the deparment, hear about the science, do chemistry on their own and hear from women doing science in chemistry. Josefine presenting her work on HIV therapeutics. We are all proud of Josefine Hammer Jakobsen for being an inspiration for the next generation of women in science ..read more
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Magnus lights Denmark on fire live on national television
Medicinal Polymer Chemistry Lab
by admin
1y ago
Friday night the residents of Denmark could see master student Magnus Schou-Jørgensen perform chemistry on the popular entertainment show “Alle mod 1” (all versus one) on DR1. As part of chemistry show at the department of chemistry, Magnus was using chemistry to transfer a flame from person to person. The show features a guest is presented with peculiar scenarios that they are tasked with predicting the outcome. In this particular case, the guest was asked to estimate the time it would take 10 chemistry students to ignite five bowls filled with alcohol, using only a flame that had to be tran ..read more
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New publication in Advanced Therapeutics!
Medicinal Polymer Chemistry Lab
by admin
1y ago
“Potentiation of Drug Toxicity through Virus Latency Reversal Promotes Preferential Elimination of HIV Infected Cells” https://doi.org/10.1002/adtp.202200113 Eliminating latently infected cells is a highly challenging, indispensable step toward the cure for HIV/AIDS. Hypothesis put forward herein is that the unique HIV protease cut site (Phe-Pro) can be reconstructed using a potent inhibitor of tubulin polymerization, monomethyl auristatin F (MMAF), which features Phe at its C-terminus. This presents opportunities to design prodrugs that are specifically activated by the HIV protease. To this ..read more
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New publication from the team in Nature Communications!
Medicinal Polymer Chemistry Lab
by admin
1y ago
“Chemical zymogens for the protein cysteinome“ https://doi.org/10.1038/s41467-022-32609-1 We present three classes of chemical zymogens established around the protein cysteinome. In each case, the cysteine thiol group was converted into a mixed disulfide: with a small molecule, a non-degradable polymer, or with a fast depolymerizing fuse polymer (ZLA). The latter was a polydisulfide based on naturally occurring molecule, lipoic acid. Zymogen designs were applied to cysteine proteases and a kinase. In each case, enzymatic activity was successfully masked in full and reactivated by small molecul ..read more
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Join the conference in Artificial Biology in August!
Medicinal Polymer Chemistry Lab
by admin
1y ago
The registration is still open for joining the first Artificial Biology Conference at the University of Aarhus. Sign up: https://events.au.dk/artbio/registration.html Read about the event, program, speakes and more at: https://events.au.dk/artbio/artbio-2022.html Follow the event on Twitter with the hashtag #ArtBio2022 We hope to see you in August ..read more
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