Myasthenia gravis (MG) is an immune disorder that causes muscle weakness with an increasing prevalence, particularly among the elderly in Japan. Glucocorticoid treatment for MG is problematic for bone health because of reduced bone density and increased fracture risk. The fracture risk assessment tool (FRAX®) can estimate fracture risk, but its applicability in patients with MG remains uncertain ..read more

The aim of our study was to measure the ability of ALS patients to process dynamic facial expressions as compared to a control group of healthy subjects and to correlate this ability in ALS patients with neuropsychological, clinical and neurological measures of the disease ..read more

Sarcoidosis is a disease characterized by non-caseating granulomas that can involve the central nervous system as neurosarcoidosis. This challenging disease is currently managed with high dose steroids, and sometimes the addition of infliximab. Other TNA-alpha inhibitors have not been studied as rigorously. We discovered ten neurosarcoidosis patients who were on an alternative TNA-alpha inhibitor, adalimumab. Eight patients had a positive response clinically and radiographically to adalimumab ..read more

..read more

Whether intracranial hemorrhage (ICH) detected using magnetic resonance imaging (MRI) affects the clinical outcomes of patients with large-vessel occlusion (LVO) treated with mechanical thrombectomy (MT) remains unclear. This study investigated the clinical features of ICH after MT detected solely by MRI ..read more

Prolonged symptoms following concussion, commonly called persistent post-concussion symptoms (PPCS), are a major public health burden that occur in up to an estimated 30% of all individuals that experience a concussion (a form of mild traumatic brain injury; mTBI) [1]. Despite this prevalence, the underlying pathophysiology and mechanism of PPCS are still unknown. This lack of knowledge significantly impairs clinician's abilities to identify patients at risk for developing PPCS and objectively monitor patients with PPCS and has also prevented development of therapeutics to reduce symptoms and ..read more

Essential Tremor (ET) is one of the most common neurological disorders. In most instances ET is inherited as an autosomal dominant trait with age-related penetrance (virtually complete in advanced age); however, ET genetics remains elusive. The current study aims to identify possibly pathogenic genetic variants in a group of well-characterized ET families ..read more

Lesion occurring in the brainstem may cause a postural tilt and balance disorders, which could be due to an inaccurate perception of the body orientation. The objective of this study was to determine the effects of a brainstem stroke on body representation in horizontal and frontal plane, and links with impaired posture and neuroanatomy ..read more

The authors regret that we neglected to include LaShyra Nolen as an author ..read more

In light of last month's publication of the Global Burden of Neurological Disease [1], and in consideration of the 2022 WHO Intersectoral Global Action Plan (IGAP) [2,3], the mandate to act on neurological disorders has never been greater. The World Federation of Neurology has just published twelve recommendations on strengthening neurological advocacy: the way of transitioning from evidence to action [4 ..read more