That in general, and concretely: 5HT receptors do downregulate from SSRI to some extent, after chronic use, and withdrawals may ensure with exaggerated stress responses. People who abuse PCP and ketamine display atrophy and neuroinflammatiom because of upregulated postsynaptic NMDA receptors and excitotoxicity. How long do particular receptors need to up- or downregulate after, say, chronic substance abuse or psychotropics? Could it be irreversible? submitted by /u/tadakuzka [visit reddit] [comments ..read more

It has always been my dream to study neuroscience. But I wasn't able to go abroad and my country does not offer any neuroscience major here. So I decided to self-study as much as possible just for myself since I'm really interested in it, and also to prepare for a post grad education in neuroscience. I've already started taking online courses on coursera and edx. Now I am looking for books, and other materials that a neuroscience major will study during their time at college. Literally course by course, if possible. Please drop some suggestions below! Or any materials/ sources that you think ..read more

I'm in a CS bachelors degree in Germany and I would love to get into neuroscience. I've started coding at the age of 14 and have worked for several companies since. So I do consider myself quite an advanced coder, but I fear my skills are mostly in areas less relevant to neurotech (e.g. I have 0 knowledge about embedded systems, just a bit knowledge about ML). I'm now planning to contribute to some open source library to A) learn more about neuroscience and B) make some contacts in the industry Is MNE a good library to contribute to or are there other ones (where I can learn more, make better ..read more

I’m writing a paper for a class on visual perception, where we discuss a visual illusion we notice and hypothesize why it might occur. It’s not a lit review, just trying to explain what we’re experiencing using course material. I’ve chosen visual snow syndrome (I see static/pixels overlaid on my visual field 24/7), and hypothesize it’s due to a lack of habituation at some point in the visual hierarchy so irrelevant visual stimuli is processed that typically would be gated out. I think this may be true because the syndrome is also associated with lots of entopic phenomena, which are thought to ..read more

Hi y'all, I have a question about an assay I'm running in lab. Essentially, we have a C. elegans strain that expresses mCherry using an egl-1 promoter. EGL-1 essentially promotes cell death from my understanding (pathway in Figure 3). I put a plate of these worms into a StrataLinker and nuked them (and then waited 30+ minutes to allow for gene expression). I expected to see increased fluorescence (increased apoptosis in response to DNA damage), but it actually looks like there's less fluorescence. Does anyone have any ideas about what's happening? Additionally, if you have StrataLinker experi ..read more

I have two offers for post-grad research: one from very prestigious researcher in my field at NIH; one from my (hopeful) desired institution for grad school -- this PI is 100% brand new, but has a strong academic background. Everyone loves both PIs. Which would better strengthen my app? Got all rejections this cycle, so very cautious submitted by /u/throwaway643274 [visit reddit] [comments ..read more

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In this video we are talking about absence seizures with eyelid myoclonia. A unique type of seizure that is typically seen in Jeavons syndrome and Dravet syndrome. Watch what happens with the patient closes their eyes. Source: Tatum, William. Handbook of EEG Interpretation Reviewed by: Ro Elgavish, MD (Epileptologist) submitted by /u/Gil_Anthony [visit reddit] [comments ..read more

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Hi! I have applied to Charité's Medical Neuroscience Program. Could anyone tell me about the entrance exams or the environment at the university? Thanks submitted by /u/Still-Ruin1615 [visit reddit] [comments ..read more