Molecular Neurodegeneration Journal on Feedspot

Mitovesicles secreted into the extracellular space of brains with mitochondrial dysfunction impair synaptic plasticity

Molecular Neurodegeneration Journal

by Pasquale D’Acunzo, Elentina K. Argyrousi, Jonathan M. Ungania, Yohan Kim, Steven DeRosa, Monika Pawlik, Chris N. Goulbourne, Ottavio Arancio and Efrat Levy

3d ago

Hypometabolism tied to mitochondrial dysfunction occurs in the aging brain and in neurodegenerative disorders, including in Alzheimer’s disease, in Down syndrome, and in mouse models of these conditions. We ha ..read more

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The concept of resilience to Alzheimer’s Disease: current definitions and cellular and molecular mechanisms

Molecular Neurodegeneration Journal

by Luuk E. de Vries, Inge Huitinga, Helmut W. Kessels, Dick F. Swaab and Joost Verhaagen

1w ago

Some individuals are able to maintain their cognitive abilities despite the presence of significant Alzheimer’s Disease (AD) neuropathological changes. This discrepancy between cognition and pathology has been ..read more

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The endotoxin hypothesis of Alzheimer’s disease

Molecular Neurodegeneration Journal

by Guy C. Brown and Michael T. Heneka

2w ago

Lipopolysaccharide (LPS) constitutes much of the surface of Gram-negative bacteria, and if LPS enters the human body or brain can induce inflammation and act as an endotoxin. We outline the hypothesis here tha ..read more

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HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases

Molecular Neurodegeneration Journal

by Anna Calliari, Lillian M. Daughrity, Ellen A. Albagli, Paula Castellanos Otero, Mei Yue, Karen Jansen-West, Naeyma N. Islam, Thomas Caulfield, Bailey Rawlinson, Michael DeTure, Casey Cook, Neill R. Graff-Radford, Gregory S. Day, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen…

3w ago

This letter demonstrates the potential of novel cryptic proteins resulting from TAR DNA-binding protein 43 (TDP-43) dysfunction as markers of TDP-43 pathology in neurodegenerative diseases ..read more

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Correction: Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution

Molecular Neurodegeneration Journal

by Araks Martirosyan, Rizwan Ansari, Francisco Pestana, Katja Hebestreit, Hayk Gasparyan, Razmik Aleksanyan, Silvia Hnatova, Suresh Poovathingal, Catherine Marneffe, Dietmar R. Thal, Andrew Kottick, Victor J. Hanson-Smith, Sebastian Guelfi, William Plumbly, T. Grant Belgard, Emmanouil Metzakopian…

3w ago

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Correction: Blood–brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism

Molecular Neurodegeneration Journal

by Qingyi Ma, Zhen Zhao, Abhay P. Sagare, Yingxi Wu, Min Wang, Nelly Chuqui Owens, Philip B. Verghese, Joachim Herz, David M. Holtzman and Berislav V. Zlokovic

3w ago

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A partial Drp1 knockout improves autophagy flux independent of mitochondrial function

Molecular Neurodegeneration Journal

by Rebecca Z. Fan, Carolina Sportelli, Yanhao Lai, Said S. Salehe, Jennifer R. Pinnell, Harry J. Brown, Jason R. Richardson, Shouqing Luo and Kim Tieu

1M ago

Dynamin-related protein 1 (Drp1) plays a critical role in mitochondrial dynamics. Partial inhibition of this protein is protective in experimental models of neurological disorders such as Parkinson’s disease a ..read more

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Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease

Molecular Neurodegeneration Journal

by Hyo Jung Shin, In Soo Kim, Seung Gyu Choi, Kayoung Lee, Hyewon Park, Juhee Shin, Dayoung Kim, Jaewon Beom, Yoon Young Yi, Deepak Prasad Gupta, Gyun Jee Song, Won-Suk Chung, C. Justin Lee and Dong Woon Kim

1M ago

Age-dependent accumulation of amyloid plaques in patients with sporadic Alzheimer’s disease (AD) is associated with reduced amyloid clearance. Older microglia have a reduced ability to phagocytose amyloid, so ..read more

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APOE4 genotype and aging impair injury-induced microglial behavior in brain slices, including toward Aβ, through P2RY12

Molecular Neurodegeneration Journal

by Jordy Sepulveda, Jennifer Yejean Kim, Joseph Binder, Stefano Vicini and G. William Rebeck

1M ago

Microglia are highly dynamic cells that play a critical role in tissue homeostasis through the surveillance of brain parenchyma and response to cues associated with damage. Aging and APOE4 genotype are the strong ..read more

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Updates on mouse models of Alzheimer’s disease

Molecular Neurodegeneration Journal

by Michael Z. Zhong, Thomas Peng, Mariana Lemos Duarte, Minghui Wang and Dongming Cai

1M ago

Alzheimer’s disease (AD) is the most common neurodegenerative disease in the United States (US). Animal models, specifically mouse models have been developed to better elucidate disease mechanisms and test the ..read more

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