I know that epigenetics doesn’t directly alter the DNA sequence in humans. But what about indirectly altering it? Such as via certain epigenetic alterations that makes a human susceptible to get a certain disease (such as a form of cancer). Can epigenetic changes indirect genetic changes? submitted by /u/Seven1s [visit reddit] [comments ..read more

I'm an undergad student and I'm struggling to figure out how does gc rich regions matter. Maybe it's a stupid question but I really need help with this. I thought it was because of the three hydrogen bonds which provides stability but then found out that stability comes from base stacking. So what exactly is the role of GC rich content? submitted by /u/thickk__jack [visit reddit] [comments ..read more

I am a PhD in pharmacology and have been reading a lot of articles on cancer genomics (specifically prostate) and find it overwhelming. For example when I try to learn about a particular assay being used in a pub, I realize that I need much more basic knowledge to completely understand the rationale. What would be the most effective way to learn genomics to get to the appropriate knowledge level? When I was working (was a medical writer, now retired) I had access to many bio-scientists’ brains (worked at big pharma). I qualify for free courses at state universities since I am senior citizen ..read more

I have a degree in Animal Science that I acquired overseas. I focused heavily on molecular biology, genetics and genomics. Although it was an animal focused degree I am fascinated by genetics regardless of the species. Now I’m in the United States looking to further my education and I don’t know where to continue. I’ve considered going into human genomic research. Is it possible to transfer over to human genetics? What is possible considering the degree I have and my idea for a possible shift in focus? submitted by /u/Parking_Temperature3 [visit reddit] [comments ..read more

submitted by /u/gwern [visit reddit] [comments ..read more

submitted by /u/gwern [visit reddit] [comments ..read more

Hi, I want to generate KM plot (Kaplan Meier) Plot using Kaplan-Meier Plotter tool for 372 miRNAs. But here, We don't have a option for generating multiple plots at once. For the genes they have but not for miRNAs. Can you please help me to do so. It's for the TCGA breast cancer Datasets. The tool link is attached. submitted by /u/Academic_Ad8284 [visit reddit] [comments ..read more

submitted by /u/gwern [visit reddit] [comments ..read more

A new book by a UNT historian argues that American medicine overlooks how the ailments of many Black Americans are influenced by the diets of their African forebears. https://www.texasmonthly.com/news-politics/ancestral-genomics-geography-black-health-disparities/ submitted by /u/Texas_Monthly [visit reddit] [comments ..read more

submitted by /u/FullNegotiation2386 [visit reddit] [comments ..read more