The phase 2 clinical trial will evaluate the safety and efficacy of ALKS 2680, an oral treatment designed to address orexin signaling deficiencies in patients with narcolepsy type 1. Summary: Alkermes plc has launched the Vibrance-1 study, a phase 2 clinical trial to assess the safety and efficacy of ALKS 2680, a novel orexin-2 receptor agonist, in treating narcolepsy type 1. This oral treatment aims to improve wakefulness by targeting the orexin system, which is often deficient in narcolepsy patients. The double-blind, placebo-controlled study will test three dosages over six weeks across mul ..read more

The dos and don’ts of enrolling sleep patients in revenue-producing RPM programs. By Sree Roy Clinical sleep medicine programs have long relied on testing and treatment reimbursement codes as major contributors to their financial bottom line. But as those revenues dwindle, remote patient monitoring (RPM) can add reimbursement streams that promote longitudinal care and pay for the CPAP troubleshooting that sleep clinicians are already doing. “As the sleep industry undergoes transformation, we see RPM as the catalyst for clinicians to evolve,” says Edward Mezerhane, MD, FAASM, FACP, medical dire ..read more

SleepCogni will collaborate with Sheffield Children’s NHS Foundation Trust to advance its handheld insomnia devices for use in young patients. Summary: SleepCogni has received over £340,000 in Innovate UK grant funding to collaborate with Sheffield Children’s NHS Foundation Trust on addressing insomnia in children and young people. SleepCogni’s handheld devices use vibration, light, and sound to disrupt the cognitive cycles that prevent sleep, while also collecting data to analyze sleep disturbances. This partnership follows a successful trial that significantly reduced insomnia symptoms in ad ..read more

Remedē is implanted under the skin in the upper chest and stimulates the phrenic nerve to regulate breathing. Summary: Allegheny Health Network has implanted the remedē device, a pacemaker-like system for treating central sleep apnea. The device, which stimulates the diaphragm with electrical currents to restore normal breathing, offers an alternative to CPAP systems. Implanted by a cardiac electrophysiologist, remedē has shown to improve patients’ quality of life and reduce daytime sleepiness in a clinical study. This collaboration between the Allegheny Health Network Sleep Medicine Center an ..read more

The Stellar Sleep app now features extended CBT-I programming and integrations with Fitbit, Oura Ring, and Apple Health. Summary: Stellar Sleep has upgraded its app to enhance chronic insomnia management, incorporating new features for better sleep tracking and expanded content access. The app employs cognitive behavioral therapy for insomnia (CBT-I). New additions include extended programming from five to 10 weeks, bookmarking for favorite lessons, a redesigned sleep center, and integrations with Fitbit, Oura Ring, and other devices. Launched in 2023 by George Wang, who overcame his own insom ..read more

Participants report improved sleep efficiency and quality with nightly use of hemp-derived gummies. Summary: Balanced Health Botanicals’ CBDistillery conducted a 31-day Pathfinder study using MoreBetter’s technology to assess the impact of their shhh+ Distilled THC + CBN Deep Sleep Gummies on sleep quality. The study found that participants experienced improved sleep quality, ease in falling back asleep, and woke up feeling more refreshed. Positive feedback was high, with 98% reporting a better quality of life and 77% preferring these gummies over other sleep aids. These findings have not been ..read more

Sleep disorders have been linked to cancer incidence. A new study investigates how the duration and severity of the sleep disturbance impact that risk.  Interview by Alyx Arnett As evidence mounts linking sleep disturbances with increased cancer risk, a new study delves into how the severity and duration of sleep disorders might influence this relationship.  James Burch, PhD Utilizing de-identified data spanning from 1999 to 2010 and involving 663,869 veterans in the southeastern United States, researchers investigated the impacts of sleep disorders on the likelihood of developing pr ..read more

Researchers at the University of Cincinnati say it is well-established in aerospace engineering that vortex airflow has unique aerodynamic properties that are different from conventional, continuous airflow. Vortex airflow is used in various applications, such as enhancing fuel mixing in combustion processes, improving convective cooling of electronic components, or as a flow control mechanism that reduces drag over a body (such as an airplane wing or a car). Then they realized the unique properties of vortex airflow could also be leveraged for CPAP therapy. “Despite the clinical efficacy for ..read more

Sunrise has partnered with Prevent Dementia to bring together research on mild-life risk factors for Alzheimer’s disease with Sunrise’s sleep monitoring expertise. The PREVENT Dementia Research Programme aspires to enhance the ability to predict individuals at the highest risk of developing dementia, ultimately leading to more effective strategies for preventing or mitigating the onset of this condition.  At the core of this partnership is the exploration of the link between sleep disturbances and dementia development. Emerging evidence suggests that sleep issues, such as sleep fragmentat ..read more

How objective sleep testing that lasts not just a night or two, but potentially for months or years, could improve patients’ sleep health. By Ann H. Carlson When it comes to precision healthcare, the more data sleep physicians can access to develop personalized treatment plans, the better. This is the philosophy behind the longitudinal sleep testing clinical model offered by Empower Sleep, a virtual, direct-to-consumer sleep practice. Home sleep testing conducted over multiple nights (or longer), longitudinal sleep testing in clinics can clarify a diagnosis, as well as provide objective data o ..read more