Mild Parkinsonian Signs in a Community Population
The Predict-Pd Blog
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4y ago
One question that many of the PREDICT-PD participants ask me is “I am slower than I used to be, does it mean that I am getting Parkinson’s?” I am interested in the early motor phases of Parkinson’s disease. They are subtle in appearance and usually start before the classical symptoms of Parkinson’s arise, which are slowness of movement, stiffness and tremor.  When studying subtle ..read more
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Patients’ views on the ethical challenges of early PD detection
The Predict-Pd Blog
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4y ago
I read this paper this morning and thought it represented an important step forward in our understanding of this delicate issue https://n.neurology.org/content/early/2020/04/14/WNL.0000000000009400 Many of us are working on risk factors of Parkinson's and early identification strategies, but what do patients with PD think about finding out they were at risk before the point of diagnosis? Here ..read more
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NEW Research - Is Parkinson's Genetic?? - Penetrance of Parkinson's Disease in LRRK2 Carriers Is Modified by a Polygenic Risk Score.
The Predict-Pd Blog
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4y ago
Here is a nice paper by colleagues from the International PD Genomics Consortium (IPDGC)... https://onlinelibrary.wiley.com/doi/abs/10.1002/mds.27974 One question I frequently get asked is "doctor, please tell me, is it genetic?"... I am instantly caught in conflict between offering swift reassurance because I know what people really mean is "will I pass this on to my children?" OR a providing a ..read more
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NEW Research - Motor complications in Parkinson's disease: 13‐year follow‐up of the CamPaIGN cohort
The Predict-Pd Blog
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4y ago
Back on the blog for the first time in a long time... This marks another NY resolution to speak and flag more about the research that I/we think is interesting or important in the early identification or prediction of PD. In addition, we like to mention good quality clinical and genetic studies that tell us more about PD in general (not just prediction and early identification).  First off, the ..read more
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Salbutamol and PD risk
The Predict-Pd Blog
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5y ago
Recently at one of our movement disorders meeting we began to discuss whether people with PD should be prescribed salbutamol. Salbutamol is a drug that has been used to treat asthma and COPD (a smoking related breathing disorder) for a long time. There has been lots of interest in Salbutamol because in epidemiological studies it appears to be protective against developing PD. Salbutamol works by ..read more
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You are what you eat
The Predict-Pd Blog
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5y ago
You are what you eat! It is a rare day that reading a scientific report of basic research makes the hairs on my neck stand up, but today is one such day.  An article published in the prestigious journal Neuroncarries the rather dry title “Transneuronal propagation of pathologic α-synuclein from the gut to the brain models Parkinson’s disease”. In their research the authors at Johns ..read more
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More PD genes to discover?
The Predict-Pd Blog
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5y ago
Epidemiological studies involving islands have a long and proud history; they always provide fascinating reading and food for thought. In the Faroe islands there were no reported cases of Multiple Sclerosis until 1943 when british troops occupied the islands. After this there was an epidemic of 21 cases. This pattern led to researchers hypothesising that british troops introduced asymptomatic ..read more
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