Hi everyone! Thank you for your advice, guidance and experience. I wish everyone a complete recovery! My name is Kirill, age 33. I am looking for help and advice.  On May 20, 2020, I had surgery to partially remove the neoplasm in the left temporo-insula. Analysis results: A diffuse glioma with infiltrative growth into the brain tissue is revealed. The tumor is represented mainly by the astrocytic component, also a little oligodendrocytic and hemistocytic. Mitotic figures are noted. Cellular density is increased. Reactive endothelium is found in the vessels. Anaplastic astrocytoma ..read more

 A study that caught my attention with impressive results in vivo albeit mice. They inhibited the p-P-Selectin protein to achieve the results. I found many supplements in my research reducing P-Selectin (EGCG, Melatonin, Lipitor, Resveratrol, Boswellia, etc). What was interesting I found is all the drugs tied with P-Selectin all dealt with inflammation. Sure enough, I found diets such as the Paleo, Low Fat, and Mediterranean diets reduced P-Selectin. I also found a study that correlates P-Selectin to cholesterol levels (LDL) as well as inflammatory responses to exercise. Study: https://ww ..read more

 Hello friends, It seems to be that supplies of Chloroquine have now completely dried up in the UK (I'm not sure whether it is beause there is no international travel, Brexit is causing problems, or it has been bought up by those believing it offers COVID-19 protection). Can anyone please help me source it somehow? Happy to message privately. I have a grade III anaplastic astrocytoma, currently showing no growth following resection 18 months ago. I have been taking it continuously until the wholesaler told our pharmacy that they didn't have any more and didn't know when it was next due to ..read more

 Not sure whether there is any research looking into this but until recently I have been using Teavigo Green Tea Extract 90% EGCG, 30 Veg Capsules by Swanson but these have been out of stock. I have started taking a different preparation (which has higher EGCG): https://www.british-supplements.net/products/clean-green-tea-extract-polyphenols-916mg-catechins-748mg-egcg-420mg But I wondered whether there was anything particular about the TeaVigo preparation that made it better for accessing the brain? Best wishes all ..read more

 My husband was diagnosed in  September 2016 at 38 years with GBM IV in frontal lobe, 8cm diameter size. He lived 4 years and 2 months from diagnosis. I remember over 4years ago I was desperatly looking for the cure for him, some knowledge and hope. With my medical background I felt that we have to take risks, that with standard care we will get standard results  - this website was an incredible source of knowledge plus Ben Williams, plus Mustella fundation, plus Inspire forum. I want to share our story. Subtotal resection on October 2016. GBM IV, Wild type, methylated. Then s ..read more

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817892/ Mebendazole and temozolomide in patients with newly diagnosed high-grade gliomas: results of a phase 1 clinical trial This was a phase 1 safety and dose finding trial rather than an efficacy trial, but could be some useful info here ..read more

 Adjuvant effect of low-carbohydrate diet on outcomes of patients with recurrent glioblastoma under intranasal perillyl alcohol therapy "Results: In the 1-year follow-up, the POH/LCD group showed a 4.4-fold decrease in the proportion of patients who needed treatment with corticosteroids, as well as a reduction in tumor size and peritumoral edema, as compared to the POH group. While 75% of patients undergoing POH treatment experienced seizures, this fraction was reduced to 56% in the POH/LCD group. A 2.07-fold increase in the proportion of patients with stable disease, along with a 2.8-fol ..read more

 New study published in clinical cancer research: Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma https://pubmed.ncbi.nlm.nih.gov/33239433/ from the abstract: Results: Despite the inherent responsiveness of GL261 to immune checkpoint blockade, concurrent dexamethasone administration with anti-PD-1 therapy reduced survival in a dose-dependent manner. Concurrent dexamethasone also abrogated survival following anti-PD-1 therapy with or without radiotherapy in immune-resistant CT-2A models. Dexamethasone decreased T-lymphocyte numbe ..read more

 Hello, everyone! I was diagnosed in May 2019 with GBM and I have completed SOC in Apr. 2020 (Total resection, 42days Chemo/Radiation, and 6 months maintenance chemo). I have done a lot of research on supplements and medications as well as reviewing many promising techniques to stop GBM. One, in particular, had caught my eye which is the CUSP9 protocol. I like this protocol because it attempts to stop GBM in its tracks not just slow or delay things until a recurrence. In addition, I find the results from this study to be one of the best and I believe the strategy used to attack a recurren ..read more

 Hi everyone, I'm so grateful to have found this blog to give me hope for my sister.  Thank you so much Stephen to have create this.  She's been diagnosed recently with glioblastoma (Methyled). She's starting her treatment in a couple of days and I have some question: Melatonin: My sister is set to have 6 weeks of radio/chemo (TMZ). Melatonin needs to be taken at night but will there be enough in her system to have an effect during the day when She's receiving the radio/chemo?  Open mind NO or doctor:  Also, is there anyone who had good luck to find an open mind about ..read more