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Algorithm ranks peer reviewers by reputation — but critics warn of bias

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by Dalmeet Singh Chawla

8h ago

Nature, Published online: 25 April 2024; doi:10.1038/d41586-024-01235-w There are questions about whether the tool, which could be used by editors to find and shortlist peer reviewers, would disadvantage inexperienced candidates or those in certain locations ..read more

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Optical clocks at sea

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by Jonathan D. Roslund, Arman Cingöz, William D. Lunden, Guthrie B. Partridge, Abijith S. Kowligy, Frank Roller, Daniel B. Sheredy, Gunnar E. Skulason, Joe P. Song, Jamil R. Abo-Shaeer, Martin M. Boyd

8h ago

Nature, Published online: 24 April 2024; doi:10.1038/s41586-024-07225-2 Sea-based optical clocks combining a molecular iodine spectrometer, fibre frequency comb and electronics for monitoring and control demonstrate high precision in a smaller volume than active hydrogen masers ..read more

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Emx2 underlies the development and evolution of marsupial gliding membranes

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by Jorge A. Moreno, Olga Dudchenko, Charles Y. Feigin, Sarah A. Mereby, Zhuoxin Chen, Raul Ramos, Axel A. Almet, Harsha Sen, Benjamin J. Brack, Matthew R. Johnson, Sha Li, Wei Wang, Jenna M. Gaska, Alexander Ploss, David Weisz, Arina D. Omer, Weijie Yao, Zane Colaric, Parwinder Kaur, Judy St. Leger, Qing Nie, Alexandria Mena, Joseph P. Flanagan, Greta Keller, Thomas Sanger, Bruce Ostrow, Maksim V. Plikus, Evgeny Z. Kvon, Erez Lieberman Aiden, Ricardo Mallarino

8h ago

Nature, Published online: 24 April 2024; doi:10.1038/s41586-024-07305-3 Patagia—the mammalian gliding membrane—repeatedly originated through a process of convergent genomic evolution, whereby the regulation of Emx2 was altered by distinct cis-regulatory elements in independently evolved species ..read more

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Mechanism of single-stranded DNA annealing by RAD52–RPA complex

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by Chih-Chao Liang, Luke A. Greenhough, Laura Masino, Sarah Maslen, Ilirjana Bajrami, Marcel Tuppi, Mark Skehel, Ian A. Taylor, Stephen C. West

8h ago

Nature, Published online: 24 April 2024; doi:10.1038/s41586-024-07347-7 Single-stranded DNA annealing is driven by RAD52 open rings in association with RPA ..read more

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Tumours form without genetic mutations

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by Anne-Kathrin Classen

8h ago

Nature, Published online: 24 April 2024; doi:10.1038/d41586-024-01019-2 Researchers find that brief and reversible inhibition of a gene-silencing mechanism leads to irreversible tumour formation in fruit flies, challenging the idea that cancer is caused only by permanent changes to DNA ..read more

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Ancient DNA traces family lines and political shifts in the Avar empire

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by Lara M. Cassidy

8h ago

Nature, Published online: 24 April 2024; doi:10.1038/d41586-024-01020-9 Genetic pedigrees spanning nine generations uncover the social organization of a nomadic empire that dominated much of central and eastern Europe from the sixth to the early ninth century ..read more

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Targeting RNA opens therapeutic avenues for Timothy syndrome

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by Silvia Velasco

8h ago

Nature, Published online: 24 April 2024; doi:10.1038/d41586-024-00911-1 A therapeutic strategy that alters gene expression in a rare and severe neurodevelopmental condition has been tested in stem-cell-based models of the disease, and has been shown to correct genetic and cellular defects ..read more

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Ecologists: don’t lose touch with the joy of fieldwork

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by Chris Mantegna

8h ago

Nature, Published online: 24 April 2024; doi:10.1038/d41586-024-01178-2 Amid the data deluge provided by lab-based techniques, such as environmental-DNA analysis, true connection still comes only in the outdoors ..read more

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Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers

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by Stephane Ferretti, Jacques Hamon, Ruben de Kanter, Clemens Scheufler, Rita Andraos-Rey, Stephanie Barbe, Elisabeth Bechter, Jutta Blank, Vincent Bordas, Ernesta Dammassa, Andrea Decker, Noemi Di Nanni, Marion Dourdoigne, Elena Gavioli, Marc Hattenberger, Alisa Heuser, Christelle Hemmerlin, Jürgen Hinrichs, Grainne Kerr, Laurent Laborde, Isabel Jaco, Eloísa Jiménez Núñez, Hans-Joerg Martus, Cornelia Quadt, Markus Reschke, Vincent Romanet, Fanny Schaeffer, Joseph Schoepfer, Maxime Schrapp, Ross Strang, Hans Voshol, Markus Wartmann, Sarah Welly, Frédéric Zécri, Francesco Hofmann, Henrik Möbitz, Marta Cortés-Cros

8h ago

Nature, Published online: 24 April 2024; doi:10.1038/s41586-024-07350-y HRO761 is a potent, selective, allosteric WRN inhibitor that binds at the interface of the D1 and D2 helicase domains, locking WRN in an inactive conformation ..read more

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High-performance fibre battery with polymer gel electrolyte

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by Chenhao Lu, Haibo Jiang, Xiangran Cheng, Jiqing He, Yao Long, Yingfan Chang, Xiaocheng Gong, Kun Zhang, Jiaxin Li, Zhengfeng Zhu, Jingxia Wu, Jiajia Wang, Yuanyuan Zheng, Xiang Shi, Lei Ye, Meng Liao, Xuemei Sun, Bingjie Wang, Peining Chen, Yonggang Wang, Huisheng Peng

8h ago

Nature, Published online: 24 April 2024; doi:10.1038/s41586-024-07343-x A fibre lithium-ion battery that can potentially be woven into textiles shows enhanced battery performance and safety compared with liquid electrolytes ..read more

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